该项目为肝癌转录调控系列研究的重要组成部分。

Background: Natural antisense transcripts (NATs) are endogenous RNA molecules that exhibit
partial or complete complementarity to other RNAs, and that may contribute to the regulation of
molecular functions at various levels. In recent years, large-scale NAT screens in several model
organisms have produced much data, but there is no database to assemble all these data.
AntiCODE intends to function as an integrated NAT database for this purpose.

Results: This release of antiCODE contains more than 30,000 non-redundant natural senseantisense
transcript pairs from 12 eukaryotic model organisms. In order to provide an integrated
NAT research platform, efficient browser, search and Blast functions have been included to enable
users to easily access information through parameters such as species, accession number,
overlapping patterns, coding potential etc. In addition to the collected information, antiCODE also
introduces a simple classification system to facilitate the study of natural antisense transcripts.

Conclusion: Though a few similar databases also dealing with NATs have appeared lately,
antiCODE is the most comprehensive among these, comprising almost all currently detected NAT
pairs.

文章发表于BMC Bioinformatics 2007, 8:319，2月获得800余次拜访。