北京协和医院肝外科顺利完成CMB第二年度工作！

附：第二个财政年度的进展报告

CHINA MEDICAL BOARD PRORESS REPORT

I. Title of Grant

  Establishment of China’s Liver Transplantation Training Center (CLTTC)

II. Grant Number, date grant was awarded and the date it ends

  Grant Number: 06-837

  Date Start: July 1, 2006

  Date End: June 30, 2011

III. Period of time the Progress Report Covers

   July 1, 2007 to June 30, 2008

IV. Name of Principal Investigator and contact information, including address, telephone number, FAX number and email

   Name of Principal Investigators: MAO Yilei, HUANG Jiefu

   Contact information:

          Address: Liver Surgery Department, Peking Union Medical College Hospital

1# Shuai-Fu-Yuan, Wang-Fu-Jing, Beijing, CHINA

          Post Code: 100730

          Telephone Number: +86-10-6529 6042

          FAX Number: +86-10-6529 6043

          Email Address:    pumchliver@hotmail.com

                                                 maoy@public3.bta.net.cn

V. Date of the Progress Report

   June 25, 2008

   p.1/, Grant #06-836 “Establishment of China’s Liver Transplantation Training Center”; 07/01/06-06/30/08

VI. The Narrative

According to the planned CMB project, we have performed the following programs within this fiscal year.

Admitting and training the trainees

Within this fiscal year, there were two batches of trainees in CLTTC, in both Northern Wing and Southern Wing of this center, namely Tianjin First Central Hospital and Sun Yat-sen University of Medical Sciences First affiliated Hospital,. Those trainees accepted this time mainly the programs of course works and clinical training, with small amount of research training. The each batch of the trainees was consisted of 36 to 38 relative professionals for each center, and used up 2 weeks in training programs.

Improving the research tasks

We went on coordinating the relative topics of liver transplantation and liver cancer with some institutes and centers. These researches included using molecular and cell biology techniques to understand more the mechanisms of liver failure, immune-reaction system, grafts rejections, immune-suppressive agents, and grafts recovery mechanism following surgery, as well as diagnosis and treatment of HCC. At present, six papers regarding the above research fields have been published in the first-ranked medical journals in China. In addition, we have performed researches for a new HCC tumor marker-GP73 and achieved big progress in this field. Our results showed that GP73 had higher sensitivity and specificity than AFP for patients with HCC in China. It has potential significance in improving early diagnosis for HCC.

Interchanging programs and relative conferences

The Brain Death Meeting has been held by Beijing University Faculty of Medicine, Peking Union Medical College, Zhejiang University Faculty of Medicine, and Tongji Medical University in Beijing on April 17, 2008. The meeting was partially sponsored by CMB. More than 300 administrative officials and clinical organ transplant professionals attended this meeting. Professor J Michael Millis and R. Michael Kalthoff from University of Chicago, faculty of Medicine were invited. They delivered a lecture on brain death and organ transplantation, and Date-speed-life building the China Donation Network (CDN). Participants also discussed deeply the following issues: a) judgment standards for brain death; b) administrative methods of brain death judgments; c) technique standards for brain death judgments.

The 7^th Sino-Japanese Symposium on Hepato-Pancreato-Boliary- Diseases & China International Forum on Hepatobiliary Surgery 2008, partially sponsored by CMB, was organized by Chinese PLA General Hospital, Japanese Surgical Association and Japan-China Medical Association. The Hepatobiliary Surgery Institute of PLA General Hospital, General Hospital of Beijing Military Region and the Hepatobiliary Surgery Institute of the Third Military Medical University are proud to host this Symposium on April 18-20, 2008 at Beijing Friendship Hotel. Eighty famous experts including internationally renowned leaders in the field from Japan, Hong Kong, Taiwan and different part of China have given splendid lectures. Prof. Mao from our Center has given an informative report regarding the role of GP73 in diagnosis of clinical HCC in China, which received a good response.

Establishing administrative and registration system of liver transplantation

  It is officially estimated that 2 million Chinese need organ transplants each year, but only 20,000 operations are performed because of a severe shortage of donated matches. That means only one in 100 patients gets the right type of organs. A national registration system for organ donations is likely to be set up by middle of 2008 to better manage human donations and transplants. The system will serve as a bridge linking potential donors and recipients. This task was partially sponsored by CMB. Donors will be registered only after they sign an agreement. A mechanism regulating and standardizing living organ donation and transplants will be introduced soon. The Red Cross will help mobilize the public to donated organs and tissues after death to help people in dire need of transplants.

VII. Significant Achievements:

Since “Human Organ Transplantation Act” was formally acted on last year, those institutions qualified by the first batch (only about 160 in number) have performed transplant operations on the basis law regulation, obeyed medical norm and ethics principle, and inhibited organ trafficking and transplant tourism. A national registration system for organ donations is likely to be set up soon.

VIII. Significant Problems:

Though we have overcome some obstacles of liver transplantation, there are a lot of problems that have to be solved as soon as possible. These problems include shortage of donor pool, imperfection of unified standard and protocol for liver transplant indications and peri-transplant managements, and the most expensive medical procedures in China. We will impel China’s liver transplant community into global community through untiring endeavor.

IX. Budget Expenditure Summary:

Expenditures Proposal Detail of the fund in the first year (USD):