Abstract

       BACKGROUND: Split liver transplantation (SLT) allows for expansion of the deceased donor pool.

       OBJECTIVES: To assess outcomes and the impact of splitting technique (in situ vs ex vivo) in SLT recipients.

       DESIGN: Single-center retrospective review (September 18, 1993, to July 1, 2010).

       SETTING: University medical center.

       PATIENTS: One hundred six SLT recipients.

       MAIN OUTCOME MEASURES: Postoperative graft and patient survival and postoperative complications.

       RESULTS: In adults, 1-, 5-, and 10-year overall patient survival was 93%, 77%, and 73%, respectively; overall graft survival was 89%, 76%, and 65%, respectively; ex vivo split patient survival was 93%, 85%, and 74%, respectively; and ex vivo graft survival was 86%, 77%, and 63%, respectively. In situ split patient and graft survival was 94% at 1 year and 75% at 5 years. Postoperative complications included biliary (29%), vascular (11%), unplanned reexploratory surgery (11%), incisional hernia (8%), small-for-size syndrome (n = 1), need for shunt at the time of SLT (n = 1), and primary nonfunction (n = 1). In children, 1-, 5-, and 10-year overall patient survival was 84%, 75%, and 69%, respectively; overall graft survival was 77%, 63%, and 57%, respectively; ex vivo split patient survival was 83%, 73%, and 73%, respectively; and ex vivo graft survival was 75%, 59%, and 59%, respectively. In situ split patient and graft survival was 86% at 1 and 5 years. Postoperative complications included biliary (40%), vascular (26%), and primary nonfunction (n = 1).

       CONCLUSIONS: Split liver transplantation remains an excellent option for expansion of the deceased donor pool for adult and pediatric populations. Postoperative morbidity remains high; however, this is justifiable owing to limited resources.

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