Repopulation of donor livers with host stem cells enables long-term acceptance of liver transplants in a rat model that normally strongly rejects organ grafts, according to new research. A combination of low-dose, short-term tacrolimus (to prevent acute rejection) and plerixafor (to mobilize host stem cells to the donor organ) prolonged graft survival and led to the partial conversion of donor livers to a host 'self' phenotype.

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